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The disease, however, may be spreading, without being primarily diffusive; for it sometimes commences in a point or circumscribed spot, as in phlegmonous inflammation; and from the influence of -certain causes, hereafter to be noticed, coagulable lymph is not formed so as to limit its extent, as in that form of the disease, and it consequently spreads more or less rapidly; the part soon losing its vitality, and the secretion from the affected vessels infiltrating and contaminating the portions adjoining it, until extensive destruction and sphacelation of this tissue takes place (buy lisinopril 20 mg uk).

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